Lymphoproliferative disorders in non-AIDS-associated Kaposi's sarcoma : the Johannesburg Hospital experience, 1980-1992

The association of the non-AIDS-related, classic form of Kaposi's sarcoma (KS) with secondary malignancies, especially lymphoproliferative disorders, has frequently been noted. However, in endemic African-type KS, such an association has been reported only rarely. A review of 62 non-AIDS-relate...

Full description

Published in: South African medical journal Vol. 84; no. 8; pp. 484 - 488
Main Authors: STEIN, M. E, SPENCER, D, DANSEY, R, PERNER, Y, GUNTHER, K, BEZWODA, W. R
Format: Journal Article
Language: English
Published: Pinelands Medical Association of South Africa 1994
Subjects:
Online Access: Get full text
Summary: The association of the non-AIDS-related, classic form of Kaposi's sarcoma (KS) with secondary malignancies, especially lymphoproliferative disorders, has frequently been noted. However, in endemic African-type KS, such an association has been reported only rarely. A review of 62 non-AIDS-related cases of KS treated and followed up at Johannesburg General Hospital between 1980 and 1992 revealed 8 patients (13%) in whom KS was associated with malignant lymphoproliferative disorders. The prevalence of secondary lymphoproliferative disorders was not significantly different among patients with classic KS (3/15; 20%) when compared with those who had African KS (4/47; 8%). In both forms of KS subtle disturbances of immunity have been described which may play a role in the pathogenesis of secondary lymphoproliferative disorders, although the factors responsible and the pathogenetic mechanisms involved in malignant lymphoid transformation in these patients have not been fully elucidated.
ISSN: 0256-9574