Two roles for caveolae in the cardiac myocyte?

The presence of caveolae in many cell types including heart myocytes is well established. It is hypothesized that caveolae may play a role in the storing of excess Ca2+ and may be instrumental in Ca2+ transients during contraction and relaxation in pathological conditions. Furthermore, the presence...

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Published in: South African medical journal Vol. 88 Suppl 1; pp. C16 - C18
Main Authors: Steinmann, C M, Lourens, N, Du Toit, P J, Theron, J J
Format: Journal Article
Language: English
Published: South Africa 02-01-1998
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Summary: The presence of caveolae in many cell types including heart myocytes is well established. It is hypothesized that caveolae may play a role in the storing of excess Ca2+ and may be instrumental in Ca2+ transients during contraction and relaxation in pathological conditions. Furthermore, the presence of substances in caveolae and in their membranes may imply a role in the importing and exporting of key molecules under physiological and pathological conditions. Secretory activity is also suggested by an electron micrograph of rat heart muscle.
ISSN: 0256-9574